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Psychedelic Drug Effects, Side Effects & Dangers The reader is directed to the section in this review on the claustrum, which demonstrates that the claustrum would be a logical target for activation by psychedelics, particularly because it is involved in corticocortical interactions. In a third study, Strachan et al. carried out a focused screen to evaluate the effect of RSK2 expression on the signaling of a set of chemically diverse 5-HT2A receptor agonists using IP accumulation, Ca2+ release, and ERK1/2 phosphorylation as readouts. They found that genetic deletion of RSK2 significantly increased relative efficacies of agonists at multiple effector pathways. 5-HT, AMS, and DOI elicited significantly greater maximal increases in IP accumulation, Ca2+ release, and ERK1/2 phosphorylation in RSK2 KO mouse embryonic fibroblasts . The relative efficacies of quipazine, 5-MeO-DMT, lisuride, and meta-chlorophenylpiperazine (m-CPP) were significantly increased at all three effector readou...